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The GSH mediated reversible oxidation of specific proteins directly related to ROS production could have a twofold benefit: on one hand it lowers the harmful effects of high ROS flux and on the other hand it allows the restoration of protein functions once the intracellular GSH content is reestablished
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We found that many of the significantly up- and down-regulated genes were also deregulated in HCCs from the Axin1Δ mouse model (Abitbol et al, 2018) (Fig S3B) and in human HCC, underscoring the biological relevance of our models and the presence of conserved HCC markers across species
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