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Many studies have reported that the downregulation of PGC-1α was associated with abnormal mitochondrial biogenesis and diminished ATP production capacity, and the reduced mitochondrial biogenesis in hepatocytes by silica nanoparticles was also associated with the inhibition of the PGC-1α/NRF-1/TFAM pathway (81)
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The S-protein harbors an FCS between the S 1 /S 2 subunits, processed during biogenesis that sets this novel viral pathogen apart from other SARS-related CoVs 71
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