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Moreover, an association between AOPPs levels and age has been documented in patients with AD, underscoring the potential utility of AOPPs as biomarkers for disease severity and progression (52)
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The GPCR for secondary bile acids, GPABR1, activates the cAMP/PKA pathway, which results in the phosphorylation of the cAMP response element binding protein and binding to the CSE promoter and increased transcription of CSE
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