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In the 1990s, liquid chromatography–mass spectrometry (LC-MS) with electrospray ionization (ESI), atmospheric pressure chemical ionization (APCI), or atmospheric pressure photoionization (APPI) revolutionized bioanalysis in analytical toxicology [59]
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Several committee members made the practical case that carried the day: patients are already using these compounds, and the realistic choice isn’t between peptides and no peptides — it’s between pharmacy-grade product prepared under controlled conditions and unregulated vials bought online. One clarification worth making: peptides were never controlled substances, so nothing is being “rescheduled” or “decriminalized.” This is about the FDA’s compounding ingredient list — a separate framework that governs what licensed pharmacies may prepare
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