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Together, these findings suggest that cellular resistance to cuproptosis also depends on a hierarchically organized copper-buffering system, in which mtGSH provides rapid, dynamic metal buffering, whereas metallothioneins confer sustained high-affinity sequestration to prevent mitochondrial copper overload
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These findings establish α-syn as a key regulator of neuronal ferroptosis and highlight ether-PLs as potential therapeutic targets in synucleinopathies (Mahoney-Sanchez et al., 2022)
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