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in vitro experiments showed that SGK1 knockdown alleviated erastin-induced downregulation of Slc7a11, GPX4, GSH, and GSSG, while reducing lipid peroxidation, iron accumulation, and mitochondrial damage upregulation, suggesting that SGK1 modulates ferroptosis processes through inflammatory pathways in CHD ( Zheng et al
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Such trajectory-wide tunnel analyses are relevant because ligand transport pathways can vary with protein conformational dynamics and are increasingly used in enzyme interpretation and rational design [32]
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