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IL-6, aside from its proinflammatory cytokine activity, may also cause an increase in BBB permeability, contributing to its disruption and further immune cell infiltration in CNS (93)

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“Biomarkers of ROS and clinical translation: from bench to bedside” section translates the framework into practice with clinically oriented biomarker panels—layering species-level reporters with damage footprints and iron metrics—and provides implementation pathways, validation standards, and disease-anchored examples (e.g., ICU use-cases and oncology/neuro/metabolic panels)