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In contrast, similar experiments in breast cancer MCF7 cells revealed only modest effects on platinum sensitivity (Peklak-Scott et al, 2008), while partial GSTP1 knockdown in the adriamycin-resistant human colorectal cancer cell line M7609 increased sensitivity not only to the selection agent, but to cisplatin, melphalan and etoposide (Ban et al, 1996)
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Its abnormal activation not only affects immune system function but also participates in the damage process of important organs such as the lungs and heart, suggesting that targeted regulation of the mTOR pathway may be a new therapeutic strategy for multi-organ protection in sepsis
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