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Ferroptosis does not require a specific pro-death signaling pathway but is triggered spontaneously when the protection of cellular membrane phospholipids from peroxidation by the metabolites and enzymes, including cysteine and glutathione peroxidase 4 (GPX4), are weakened [228, 229]

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doi: 10.1016/j.ijpharm.2023.123188 [DOI] [PubMed] [Google Scholar] 142.Fernandes JC, Wang H, Jreyssaty C, et al