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Primarily, CHAC1 is transcriptionally regulated by ATF4, a key player in the integrated stress response (ISR), which is activated during conditions like amino acid deprivation and oxidative stress (Crawford et al., 2015)
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Vegans’ gut microbiota have also been shown to produce much less TMAO, even following a “carnitine challenge.” A 2013 study by Koeth et al
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