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Cargo composition plays a critical role: EVs enriched in LPS/LTA activate TLR4/TLR2-NF-κB signaling promoting M1 polarization, while EVs enriched in sphingolipids or specific miRNAs (e.g., miR-146b) activate STAT6/PPARγ signaling favoring M2 polarization
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[DOI] [PMC free article] [PubMed] [Google Scholar] 108.Prigge JR, Coppo L, Martin SS, Ogata F, Miller CG, Bruschwein MD, Orlicky DJ, Shearn CT, Kundert JA, Lytchier J, Herr AE, Mattsson A, Taylor MP, Gustafsson TN, Arner ESJ, Holmgren A, Schmidt EE
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