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Oxidative stress changes in different stages of carcinogenesis During the initiation stage of cancer, which is characterized by increasing levels of oxidative stress, genetic alterations facilitate cellular survival (adaptation to oxidative stress) via the activation of antioxidant transcription factors and/or the increase in NADPH production, which is required for fueling the antioxidant machinery (Iqbal et al
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Sep 2014;33(3):223-227
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