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GLP-1 receptor agonists also inhibit the formation of asymmetric dimethylarginine (ADMA) by modulating the advanced glycation end products (AGE) and their interaction with receptor for the AGE (RAGE), also through the PKA and blunting of NF-κB, thus suppressing the expression of the arginine methyltransferase-1 protein and inhibiting the production of reactive oxygen species
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