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“Severe low testosterone symptoms may necessitate starting with TRT, while significant weight loss goals might prioritize a GLP-1 like semaglutide.” Starting both simultaneously has a practical complication: if a side effect occurs, it can be difficult to know which drug caused it, says Staheli

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At a glance: FDA-approved, with published phase 3 trial data Weekly subcutaneous injection or a daily tablet Works by reducing appetite rather than by targeting fat cells Available by prescription only Understanding what semaglutide does to your body helps set expectations, because the effects on blood sugar and digestion build over months rather than days