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Toll-like receptor 9 plays a key role in the autonomic cardiac and baroreflex control of arterial pressure
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In preclinical models, fuzuloparib potently inhibits PARP-1, induces DNA double-strand breaks, triggers G2/M cell-cycle arrest and apoptosis in homologous recombination-deficient cells, and effectively sensitizes tumor cells to cytotoxic agents, while showing a favorable pharmacokinetic and toxicology profile [163]
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