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In PSMA-negative PC3 cells, 5b remained largely inactive, while 5a retained near- MZ1 potency, in line with the profile observed for 2a (Figures D–F and S26A in SI
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Over 19 weeks, cotadutide significantly reduced hepatic steatosis (−4.8%), ALT (−15.5%), AST (−14.0%), body weight (−2.9 kg), and BMI (−1.0 units)
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