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Related, medium spiny neurons in the nucleus accumbens are implicated in modulating resilience to chronic social defeat, and optogenetic stimulation of these neurons can bidirectionally alter the outcome of this stressor on depressive-like behaviors [105]

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It is known that UV radiation can hyper activate the melanocytes through different ways including the regulation of melatonin-stimulating hormone receptors (MSHR), also known as Melanocortin-1 receptor (MC-1R), which can induce hormone binding and enhanced endogenous protein kinase A (PKA) and tyrosine kinase expression which can in turn lead to the phosphorylation of cAMP and control of melanogenesis that can induce higher melanin production