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Overall, we have demonstrated that rat sagittal whole brain slice cultures are effective tools for modelling acute demyelination and chronic demyelination of the corpus callosum using CPZ or LPC, respectively
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As such, inactivation of glutathione peroxidase 4 (GPX4), an enzyme required for the clearance of lipid ROS, can induce ferroptosis even when cellular cysteine and GSH contents are normal (Friedmann Angeli et al., 2014
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