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Additionally, metformin can improve endometrial receptivity by increasing the expression of GLUT4 in the endometrium, regulating the expression of hormone receptors related to endometrial decidualization, and modulating autophagy and nucleic acid/protein transcription processes, which in turn improves the reproductive outcomes of PCOS

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Redox potentials of the glutathione redox couple (2GSH → GSSG + 2e − + 2H + ) in mitochondria can be calculated by using experimentally determined concentrations of GSH and GSSG in the Nernst equation [30, 33]: Eo is the standard potential of GSH (− 288 mV, at pH 7.8 in mitochondria), R is the gas constant (8.31 J/deg mol), T is the absolute temperature (310 K), n is the number of electrons transferred (2), and F is the Faraday constant (96,406 J/V)