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One pathway via which NF-κB can be activated is the Toll-like receptor (TLR) pathway
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In a native environment of intact cartilage, the heterotypic interactions of CII with other matrix molecules such as decorin [99], fibromodulin [100], collagen XI [101], and collagen IX [102,103] produce more complex structured microfibril, which potentially constrains the accessibility of collagen to the recognition of antibody, due to masking of most of the collagen surface (heterotypic fibrils) by other extracellular matrix molecules
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