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The “sandwich” structured hydrogel further innovates the temporal release system, with the outer layer of SODm achieving rapid ROS scavenging (70% release within 24 h), while the inner layer, which is MMP-2 responsive, releases TGF-β1 in a delayed manner, peaking at 48 h, which significantly enhances the expression of aggregated proteoglycans (Yang et al., 2024)
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