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For cardiovascular system, the oxidation of low-density lipoproteins (oxLDL) by ROS and the activation of endothelial cells in the artery, are recognized as initiation of atherosclerosis in SLE (76)

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While it is difficult to determine the most effective biologic or small molecule in the treatment of scalp psoriasis because of varying differences in outcome measures and lack of head-to-head studies, guselkumab, infliximab, ixekizumab, and brodalumab appear, on average, to have the highest efficacy in the clearance of scalp psoriasis across studies (Table 1)