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It is a smaller and less modified peptide than the GLP-1 analogs, but quality expectations have risen significantly: Purity — RP-HPLC on a C18 column at 220 nm

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Why this trial matters: • First triple hormone receptor agonist showing major Phase III weight-loss efficacy • Delivers weight-loss outcomes far beyond many current therapies • Suggests a potential new metabolic and obesity care benchmark Semaglutide Shows Consistent Liver Benefits in MASH In the Phase III ESSENCE study, once-weekly semaglutide 2.4 mg significantly increased rates of steatohepatitis resolution and fibrosis improvement on liver biopsy in adults with metabolic dysfunction-associated steatohepatitis (MASH), compared with placebo