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As many Rickettsia species target endothelial cells during systemic infection 38 , we determined the effects of BSO on infected human microvascular endothelial cells (HMEC-1)
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Iron exhibits redox activity and engages in the production of intracellular free radicals and lipid peroxides ( via the Fenton reaction, which means reactions of Fe 2+ and peroxides to generate oxygen-centered radicals (Winterbourn, 1995)
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