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Furthermore, predictive tests are often performed on a single chemical entity, whereas ultimate use may occur as part of a multicomponent formulation in a marketed product, where the vehicle and associated ingredients may influence the outcome

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Although a combination therapy regimen is recommended to reduce recurrence and prolong DFS in TNBC, some drugs have side effects, as seen in doxorubicin or platinum agents such as cisplatin, which inhibits DNA synthesis by forming intra- and inter-strand bonds in DNA, but are highly toxic, presenting neurological toxicity (ototoxicity) and nephrotoxicity