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HHcy and subsequent hypomethionemia are independent risk factors for endothelial damage through the excessive proliferation of smooth muscle cells, H 2 O 2 production, as well as protein and lipid oxidation [115]
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Thus, BPC 157 therapy was effective regardless of whether the NO-system was inactivated (L-NAME + L-arginine), overstimulated (L-arginine), or blocked (L-NAME) [11,29]
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