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Knockout of Gpx4 in mouse neurons can cause symptoms of amyotrophic lateral sclerosis, mainly characterized by rapid paralysis, severe muscle atrophy, and death, which is related to ferroptosis of spinal motor neurons [62]
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This effect may be attributed to the downregulation of SLC7A11 expression, leading to a decrease in intracellular GSH levels and subsequent impairment of ROS scavenging capabilities
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