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Specifically, the Ce 3+ /Ce 4+ redox pair presented SOD-like enzymatic activity and rapidly decomposed ROS and alleviated the oxidative stress in M1 macrophages, while RH inhibited the TLR4 signaling in M1 macrophages, both of which could act in a concerted manner to induce their repolarization into anti-inflammatory M2 phenotype to ameliorate local inflammation (Fig
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