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A Perilous Syndrome Occurred Centrally Brain Lesions, Cerebral and Cerebellar Cortex, Hypothalamus/Thalamus, and Hippocampus We assumed a failed common clue (i.e., intracranial (superior sagittal sinus), portal, and caval hypertension, aortal hypotension, progressed thrombosis, peripherally and centrally, failed collateral recruitment, disturbed ECG presentation, peripheral organ lesions)

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One of the enzymes we focused on is phospholipase C, which plays a crucial role in modifying phospholipids and regulating cell growth, differentiation, and endocytosis.41,42 Previous studies have demonstrated a decrease in the expression of this enzyme in the brain tissue of Alzheimer's patients.43 Therefore, the reduced levels of phospholipase C in tinnitus patients may lead to impaired cognitive function, which is also a common symptom among individuals with tinnitus.44 Tinnitus can also result in a decrease in serine protease