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Cell growth was completely inhibited at 10-30 µg/ml but was not affected at a concentration 0.17 mg/kg bw per day produced a dose-dependent increase in serum estradiol concentration, and all doses produced a dose-dependent decrease in serum progesterone concentration on test day 90, which correlated with ovarian atrophy and lack of corpora lutea

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Certain individuals—such as those with a history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2—should not use GLP-1 receptor agonists