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This disruption weakens NPR1-dependent immune responses, which are crucial for the salicylic acid (SA)-mediated regulation of defense genes in apples
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These cells secrete proinflammatory cytokines, including IFN-γ, IL-1β, IL-12, CCL4, CCL5, and GM-CSF, which are associated with hepatocyte damage, increased ROS production, apoptosis, and activation of JAK-STAT1/3 and NF-κB signaling pathways (109)
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