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This transition, triggered during R-loop formation/ssDNA recruitment, shifts the enzyme from an autoinhibited state—where the helix-like loop occludes the HD domain’s catalytic site—to an active state characterized by outward displacement of this loop, exposing the nuclease core
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[DOI] [PubMed] [Google Scholar] 28.Asghari S., Asghari-Jafarabadi M., Somi M.-H., Ghavami S.-M., Rafraf M
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