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Astrocytes, however, have the ability to utilize a far greater number of substrates in the synthesis of GSH including the amino acids: glutamate, cysteine, glycine, glutamine, aspartate, asparagine, ornithine, proline and cysteine, conjugates of these amino acids as well as glutathione disulfide (GSSG), 2-oxothiadolazine-4-carboxylate (OTC), N-acetylcysteine (NAC) and GSH itself [3, 94–96], although each of these components are ultimately converted to glutamate, cysteine or glycine prior to GSH synthesis [97]

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