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The combined four-component algorithm adjusts for age and folate status, in view of the likely increase in serum MAA with age in the elderly, and the increase in serum Hcy in folate deficiency

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This is consistent with what we see in practice: combining radiofrequency, ultrasound, and microneedling tends to produce fuller, longer-lasting results than single-energy approaches because it works on multiple layers of the skin at once