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During maturation, the NOTCH precursor undergoes a complex process of modifications and cleavages, like the S1 cleavage catalyzed by a furin-like protease before translocation of the mature protein to the cell membrane (Figure 6)
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Time-series images were acquired every 5 s (XYZT imaging, stack of 5 confocal images with a size of 512 × 512 pixels)
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