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The hepatocyte-specific deletion of the endogenous inhibitor of RIPK1 kinase, such as TAK1- which performs inhibitory phosphorylation on RIPK1- results in spontaneous hepatocyte apoptosis, steatohepatitis, fibrosis, and HCC 67,68

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Additionally, tamoxifen’s ability to stop mammary tumors was significantly increased by the vitamin D analog 1,25-dihydroxy-16-ene-23-yne-26,27-hexafluorochole-calciferol, demonstrating that vitamin D and antiestrogenic compounds may protect against breast cancer through different pathways (37)