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[12] The lipid modification of all Wnts is palmitoleoylation of a single totally conserved cysteine residue
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Although many pathological stimuli can trigger necroptosis, the most typical pathway for inducing necroptosis is TNF and FAS signaling, in which CASP8 inhibition activates necrosomes (a multi-protein complex containing RIPK1, RIPK3, and MLKL) to trigger necroptosis [113]
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