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Mushroom Intolerance: Ergothioneine and the OCTN1 Gene | Genetic Lifehacks

The initial reaction following pronounced hepatic parenchymal necrosis is oval cell hyperplasia (Engelhardt 1997)

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In part, this reflects excitation/inhibition balance and classical aminergic neuromodulatory tone in the brain, both of which are deranged by excess nitrogen and can ultimately cause excitotoxicity if nitrogen imbalances are not promptly addressed (Rangroo Thrane et al., 2013)