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Tregs directly inhibit the activation and proliferation of CD8+ cytotoxic T cells and Th1 cells by highly expressing immune checkpoint molecules (such as CTLA-4, PD-1) and secreting suppressive cytokines (IL-10, TGF-β) [179]
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They reported that p53 suppresses accumulation of cytoplasmic chromatin fragments (CCF), including DNA damage signaling marker γH2A.X, and its downstream inflammatory phenotype (e.g., SASP) of monocytes and macrophages in liver
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