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SOCS3 SOCS proteins bind to signalling elements in cytokine signalling pathways and inhibit their function
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A recent study showed that in the 4T1 breast cancer model the enzymatic depletion of oxysterols in primary tumors decreases the formation of lung metastases by regulating the levels of immune cells infiltrating the metastatic TME, and tumor-associated neutrophils are the main driving force of local immunosuppression (296)
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