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Additionally, the metabolite of cholesterol, 7α, 25-dihydroxycholesterol (7α, 25-OHC), is dramatically elevated in the plasma of SLE patients and binds to the G protein-coupled receptor (GPCR) Epstein–Barr virus-induced gene 2 (EBI2) in macrophages to alleviate the IFN and ISG response for protecting against SLE progress (118)
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As a result it was considered that GHRP-2 directly attenuates Atrogin-1 and MuRF1 mRNA levels through ghrelin receptors in myocytes
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