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PFK1 and decidualization Phosphofructokinase-1 (PFK1) catalyzes the second committed step of glycolysis, converting fructose-6-phosphate (F6P) into fructose-1,6-bisphosphate (FBP)
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The activation of MAPK and SIRT1 has been implicated in metabolic programming, promoting mitochondrial biogenesis, lipid oxidation, and anti-inflammatory responses, thereby playing a protective role against obesity-induced insulin resistance and chronic inflammation (44)
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