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Stage 4 is less clearly defined, although studies suggest that the abnormal proteolytic activity is associated with increased levels of intracellular calcium, as well as binding of hemichromes (arising from denaturation of hemoglobin) to band 3 molecules

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However, a critical gap across these studies is the general lack of investigation into whether and how these autophagy-modulating agents affect ferroptosis, which limits the assessment of their full relevance to the core crosstalk theme