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Validation in vivo was performed using the administration of MMA by intraperitoneal injections twice daily for four weeks in either non-tumor bearing mice or mice challenged with luciferase-expressing lung cancer cells

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Given the responses to therapeutic approaches, ITP patients can be diagnosed as either “Responder, R” (with the PLT count ≥ 30 × 10 3 /µL or at least a twofold increase from the baseline count and no bleeding symptoms) and “Non-responder, NR” (with the PLT ˂ 30 × 10 3 /µL, or less than a twofold increase from the baseline count, or presence of bleeding symptoms) states 10,11

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