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Moreover, they used the NP formulation to treat mice with tumors derived from B16F10 cells, obtaining a remarkable tumor accumulation and a strong reduction in tumor growth
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Some antiviral drugs, ACE inhibitors, angiotensin II receptor antagonists, HMG-CoA reductase inhibitors, NSAIDs, and antitumor drugs (paclitaxel, methotrexate etc.) are its substrates (Jonker and Schinkel, 2004
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