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[DOI] [PubMed] [Google Scholar] 40.Li L.-Y., Limbu S.M., Ma Q., Chen L.-Q., Zhang M.-L., Du Z.-Y
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Despite these complexities, a common method to estimate the change in total drug CL between specific patient populations is to quantify the change in the function of the organ that has a significant role in the total drug CL (for example, determining kidney function by estimating GFR for a drug that is predominantly cleared by the kidney)
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