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the 尽管理论上有DIC/DMAP或DIC/HOBt或DIC/HOAt或BOP/HOBt或BOP/HOAt或HBTU/HOBt或HBTU/HOAt或HATU/HOBt或HATU/HOAt或HCTU/HOBt或HUTC/HOAt或TBTU/HOBt等试剂可以选择,而且理论上也没有重大区别。但是令人意想不到的是,尽管小试阶段各试剂效果差异不显著,但是进入中试阶段(即,实验放大),我们发现,相对于其他试剂组合,用TBTU/HOBt反应粗品纯度较好,小试试验粗品纯度达到78%以上,而中试批量生产粗品纯度也能在基本不降低产率的条件下达到75%,经过纯化的成品,纯度大于98%,不低于95%的药用纯度要求。 Although theoretically there are DIC/DMAP or DIC/HOBt or DIC/HOAt or BOP/HOBt or BOP/HOAt or HBTU/HOBt or HBTU/HOAt or HATU/HOBt or HATU/HOAt or HCTU/HOBt or HUTC/HOAt or TBTU/ Reagents such as HOBt can be chosen, and theoretically there is no major difference
Goal: Brighten & Even Tone
Size:1 pcs
BPC-157 + TB-500 BPC-157 + TB-500
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