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However, a correlation between higher plasma cysteine levels and increased breast cancer risk was not observed in another prospective nested case–control study, wherein an inverse cysteine–cancer risk relationship was particularly evident in leaner women 183 or related to the catechol-O-methyltransferase (COMT) genotype compatible with high enzymatic activity

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While it does not directly alter the fundamental understanding of GSH therapy, it may encourage more targeted investigations into how GSH interacts with specific metabolic pathways and patient subgroups, as well as its effects on NAFLD risk factors and comorbidities