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Intriguingly, a competitive relationship between the homologues CHAC1 and CHAC2 was observed in human embryonic stem cells (hESCs), where they play opposing roles in maintaining cellular GSH levels and regulating differentiation (Wang et al., 2017)
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PKA and CaMK phosphorylate and activate ATF/CREB transcription factors to induce steroidogenic acute regulatory protein (StAR) and aldosterone synthase gene (CYP11B2) expression, which are early and late rate-limiting steps in aldosterone biosynthesis ( Figure 3 ) [41]
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