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In the U-shaped Aβ 40 fibrils the β1 and β2 strands are staggered, and a for the U-shape geometry characteristic salt bridge D23-K28 connects chain (i) and (i+2) in L-fibrils, but chains (i) and (i-2) in DRI fibrils, see also Figure 8e in a later section of this paper

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“We believe maintaining the glutathione-to-iron ratio is very important, because if you have too little glutathione, then iron becomes very reactive, and if you have too much glutathione, the iron will not be usable.” Their experiments determined that SLC25A39 carries a unique iron signature on its surface as part of the glutathione sensing mechanism